Cover of: role of microenvironment in axonal regeneration | Christine C. Stichel-Gunkel

role of microenvironment in axonal regeneration

influences of lesion-induced changes and glial implants on the regeneration of the postcommissural fornix
  • 81 Pages
  • 4.51 MB
  • 964 Downloads
  • English
by
Springer , Berlin, New York
Nervous system -- Regeneration., Axons., Neuroglia., Axons -- physiology., Nerve Regeneration., Tissue Transplanta
StatementChristine C. Stichel-Gunkel.
SeriesAdvances in anatomy, embryology, and cell biology ;, vol. 137, Advances in anatomy, embryology, and cell biology ;, v. 137.
Classifications
LC ClassificationsQL801 .E67 vol. 137, QP363.5 .E67 vol. 137
The Physical Object
Paginationviii, 81 p. :
ID Numbers
Open LibraryOL664775M
ISBN 103540627871
LC Control Number97010368

The Role of Microenvironment in Axonal Regeneration Influences of Lesion-Induced Changes and Glial Implants on the Regeneration of the Postcommissural Fornix Authors: Stichel-Gunkel, Christine C.

The Role of Microenvironment in Axonal Regeneration Influences of Lesion-Induced Changes and Glial Implants on the Regeneration of the Postcommissural Fornix Authors. The Role of Microenvironment in Axonal Regeneration Influences of Lesion-Induced Changes and Glial Implants on the Regeneration of the Postcommissural Fornix by Brand: Springer Berlin Heidelberg.

The Role of Microenvironment in Axonal Regeneration: Influences of Lesion-Induced Changes and Glial Implants on the Regeneration of the in Anatomy, Embryology and Cell Biology) by Christine C.

Stichel-Gunkel. Springer, Softcover reprint of the origina. Paperback. Used:Good. The role of microenvironment in axonal regeneration. Influences of lesion-induced changes and glial implants on the regeneration of the postcommissural by: 1.

The Role of Microenvironment in Axonal Regeneration. por Christine C. Stichel-Gunkel. Advances in Anatomy, Embryology and Cell Biology (Book ) ¡Gracias por compartir.

Download role of microenvironment in axonal regeneration EPUB

Has enviado la siguiente calificación y reseña. Lo publicaremos en nuestro sitio después de haberla : Springer Berlin Heidelberg. Cite this chapter as: Stichel-Gunkel C.C. () Aims of the Study. In: The Role of Microenvironment in Axonal Regeneration.

Advances in Anatomy Embryology and Cell Biology, vol E-Mail Address. Password. Forgotten Password. Remember Me. Myelin proteins in the adverse microenvironment inhibit the axonal regeneration through the RhoA-ROCK pathway.

They are also involved in the process of NSCs differentiation, by promoting the differentiation of NSCs into the glial lineage and inhibiting their differentiation into neuronal lineage via the mTOR-STAT3 pathway [ 2 ].

The microenvironment in which a tumor originates plays a critical role in its initiation and progression. Tumor Microenvironment reviews the importance of tumor microenvironment in cancer management. Particular emphasis is placed on discussing how the unique characteristics of the tumor microenvironment not only impact disease progression and response to conventional anticancer.

The book Axonal Regeneration in the Central Nervous System is the book to have for those interested in spinal cord injury and axonal regeneration in general. Eventually, perhaps 50 years from now, this book may become the framework for a Foreword of a new book, documenting the important steps and the thinking that led to Superman really walking.

The role of microenvironment in axonal regeneration: influences of lesion-induced changes and glial implants on the regeneration of the postcommissural fornix Author: Christine C Stichel-Gunkel. The role of microenvironment in axonal regeneration: influences of lesion-induced changes and glial implants on the regeneration of the postcommissural fornix.

[Christine C Stichel-Gunkel] -- Since the pioneering studies of Ramon y Cajal the inability of lesioned adult CNS axons to regenerate. Peripheral axon injury initiates a regenerative response that is absent in CNS axons.

Mahar and Cavalli describe the mechanisms that initiate. The tumor microenvironment (TME) consists of extracellular matrix proteins, immune cells, vascular cells, lymphatics and fibroblasts.

Under normal physiological conditions, tissue homeostasis protects against tumor development. However, under pathological conditions, interplay between the tumor and its microenvironment can promote tumor initiation, growth and metastasis.

Pía M. Vidal graduated in Bioengineering with specialization in Cellular and Molecular Biology at the University of Concepción, Chile.

Currently she is a Ph.D. student in the Dept. of Morphology at Hasselt University, Belgium. Her research interests include the role of anti and pro- inflammatory cytokines in spinal cord regeneration, as well as the effect/modulation of the immune system in.

Details role of microenvironment in axonal regeneration EPUB

Where, nerve growth factor (NGF) is one of the most important biological active substances in the nervous system, which plays a decisive role in promoting the proliferation and differentiation of neurons, regulating central and peripheral neuronal survival and accelerating axon regeneration (Aloe.

This regeneration-promoting effect is efficiently blocked in SOCS3-gp double-knockout mice, suggesting that SOCS3 deletion promotes axon regeneration via a gpdependent pathway.

Axon regeneration by adult mammalian neurons in the central nervous system was firmly established in the early s in elegant experiments carried out by Albert Aguayo, Sam David, Peter. Role of Lipoproteins in the Delivery of Lipids to Axons during Axonal Regeneration* our studies support the idea that during axonal regeneration lipoproteins can be taken up by axons from the microenvironment and supply sufficient cholesterol, but not phosphatidylcholine, for growth.

Neuron Review Intrinsic Control of Axon Regeneration Zhigang He1,* and Yishi Jin2,3 * 1F.M. Kirby Neurobiology Center, Boston Children’s Hospital, and Department of Neurology, Harvard Medical School, Longwood Avenue, Boston, MAUSA 2Section of Neurobiology, Division of Biological Sciences 3Howard Hughes Medical Institute University of California, San Diego, La Jolla, CA.

Axonal regeneration Santiago Ramón y Cajal made several fundamental observations that have defined the perception of axonal regeneration in the central nervous system (CNS) of the past decades. While during development and in the peripheral nervous system, regeneration of nerve fibers does occur, in the adult CNS they do not regenerate.

Revealing essential roles of the tumor microenvironment in cancer progression, this book focuses on the role of hematopoietic components of the tumor microenvironment. Further, it teaches readers about the roles of distinct constituents of the tumor microenvironment.

Description role of microenvironment in axonal regeneration PDF

The correct wiring of neuronal circuits depends on outgrowth and guidance of neuronal processes during development. In the past two decades, great progress has been made in understanding the molecular basis of axon outgrowth and guidance.

Genetic analysis in Caenorhabditis elegans has played a key role in elucidating conserved pathways regulating axon guidance, including Netrin. Adult mammalian axon regeneration is generally successful in the peripheral nervous system (PNS) but is dismally poor in the central nervous system (CNS).

However, many classes of. In the face of acute or chronic axonal damage, neurons and their axons undergo a number of molecular, cellular, and morphological changes.

These changes facilitate two types of responses, axonal degeneration and regeneration, both of which are remarkably conserved in both vertebrates and invertebrates.

Invertebrate model organisms, including Drosophila and C. elegans, have offered a. Similarly, axon regeneration robustly occurs when PTEN is deficient in mouse cortical motor neurons, Drosophila sensory neurons, and Caenorhabditis elegans motor neurons.

The melanopsin/GPCR (cell-type-specific G protein-coupled receptor) signaling enhances axonal regeneration of RGCs through promotion of mTORC1 signaling. Spinal cord injury (SCI) is a central nervous system- (CNS-) related disorder for which there is yet no successful treatment.

Within the past several years, cell-based therapies have been explored for SCI repair, including the use of pluripotent human stem cells, and a number of adult-derived stem and mature cells such as mesenchymal stem cells, olfactory ensheathing cells, and Schwann cells.

S.L. Carroll, S.H. Worley, in Reference Module in Neuroscience and Biobehavioral Psychology, Abstract. Wallerian degeneration refers to the well-orchestrated morphologic and biochemical changes that occur in axons, Schwann cells, and macrophages distal to a site of nerve injury, resulting in the establishment of a microenvironment supportive of axonal regeneration.

Axon Regeneration in the CNS: Insights from the Optic Nerve Mst3b in optic nerve regeneration, the role of TNF-alpha in animal models of glaucoma, the role of inosine in. The role of the Rho/ROCK signaling pathway in inhibiting axonal regeneration in the central nervous system.

(PMID PMCID:PMC) the main cause of impaired regeneration is the presence of factors that strongly inhibit regeneration in the surrounding microenvironment. These factors signal through the Rho/ROCK signaling pathway to.Full Description: "Stability of the internal environment in which neuronal elements are situated is unquestionably an important prerequisite for the effective transmission of information in the nervous system.

During the past decade our knowledge on the microenvironment of nerve cells has expanded. The conception that the microenvironment of neurones comprises a fluid with a relatively simple.Herein, this study aims to investigate the immunoregulatory role of 2-N,6-O-sulfated chitosan (26SCS), a sulfated polysaccharide, in the osteogenetic capacity of BMP-2 and the subsequent effects on bone regeneration.

It was noted that 26SCS can robustly activate a moderate pro-inflammatory macrophage response initially, followed by.